G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide.

ABSTRACT: G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key biological activity. Since data on viruses are scattered, we here present a comprehensive analysis of potential quadruplex-forming sequences (PQS) in the genome of all known viruses that can infect humans. We show that occurrence and location of PQSs are features characteristic of each virus class and family. Our statistical analysis proves that their presence within the viral genome is orderly arranged, as indicated by the possibility to correctly assign up to two-thirds of viruses to their exact class based on the PQS classification. For eac

SUBMITTER: Lavezzo E 

PROVIDER: S-EPMC6307822 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature