Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events.

ABSTRACT: Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, cl

SUBMITTER: Ramos-Vicente D 

PROVIDER: S-EPMC6307864 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature