An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a heterogeneous smoking-related disease characterized by airway obstruction and inflammation. This inflammation may persist even after smoking cessation and responds variably to corticosteroids. Personalizing treatment to biologically similar "molecular phenotypes" may improve therapeutic efficacy in COPD. IL-17A is involved in neutrophilic inflammation and corticosteroid resistance, and thus may be particularly important in a COPD molecular phenotype.

Methods

We generated a gene expression signature of IL-17A response in bronchial airway epithelial brushings from smokers with and without COPD (n = 238), and validated it using data from 2 randomized trials of IL-17 blockade in psoriasis. This IL-17 signature was rela

SUBMITTER: Christenson SA 

PROVIDER: S-EPMC6307967 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature