Whole-Brain Neuronal Activity Displays Crackling Noise Dynamics.

ABSTRACT: Previous studies suggest that the brain operates at a critical point in which phases of order and disorder coexist, producing emergent patterned dynamics at all scales and optimizing several brain functions. Here, we combined light-sheet microscopy with GCaMP zebrafish larvae to study whole-brain dynamics in vivo at near single-cell resolution. We show that spontaneous activity propagates in the brain's three-dimensional space, generating scale-invariant neuronal avalanches with time courses and recurrence times that exhibit statistical self-similarity at different magnitude, temporal, and frequency scales. This suggests that the nervous system operates close to a non-equilibrium phase transition, where a large repertoire of spatial, temporal, and interactive modes can be supported. Finall

SUBMITTER: Ponce-Alvarez A 

PROVIDER: S-EPMC6307982 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature