Nrf2 regulates CD4⁺ T cell-induced acute graft-versus-host disease in mice.

ABSTRACT: Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a ubiquitously expressed transcription factor that is well known for its role in regulating the cellular redox pathway. Although there is mounting evidence suggesting a critical role for Nrf2 in hematopoietic stem cells and innate leukocytes, little is known about its involvement in T-cell biology. In this study, we identified a novel role for Nrf2 in regulating alloreactive T-cell function during allogeneic hematopoietic cell transplantation (allo-HCT). We observed increased expression and nuclear translocation of Nrf2 upon T-cell activation in vitro, especially in CD4⁺ donor T cells after allo-HCT. Allo-HCT recipients of Nrf2 ^-/- donor T cells had significantly less acute graft-versus-host disease (GV

SUBMITTER: Tsai JJ 

PROVIDER: S-EPMC6307985 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature