Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise.

ABSTRACT:

Objective

Hypothalamic Pro-opiomelanocortin (POMC) and Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) neurons are critical nodes of a circuit within the brain that sense key metabolic cues as well as regulate metabolism. Importantly, these neurons retain an innate ability to rapidly reorganize synaptic inputs and electrophysiological properties in response to metabolic state. While the cellular properties of these neurons have been investigated in the context of obesity, much less is known about the effects of exercise training.

Methods

In order to further investigate this issue, we utilized neuron-specific transgenic mouse models to identify POMC and NPY/AgRP neurons for patch-clamp electrophysiology experiments.

Results

Using whole-cell patch-clamp electrophysiolo

SUBMITTER: He Z 

PROVIDER: S-EPMC6308029 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature