MicroRNAs for the Diagnosis and Management of Malignant Pleural Mesothelioma: A Literature Review.

ABSTRACT: Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with a variable incidence among different countries. Occupational asbestos exposure is the most important etiological factor and a very long latency period is widely reported. In the early phase of the disease, clinical signs are absent or not specific. For this reason, the diagnosis is frequently achieved only in the advanced stages. The histopathological diagnosis per se is also very complex, and no known factor can predict the prognosis with certainty. Nonetheless, current survival rates remain very low, despite the use of standard treatments, which include surgery, chemotherapy and radiotherapy. The identification of new prognostic and/or diagnostic biomarkers, and the discovery of therapeutic targets is a prior

SUBMITTER: Lo Russo G 

PROVIDER: S-EPMC6308141 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature