Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions.

ABSTRACT: Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched, activated microglia and macrophages, have been linked to greater tissue damage. Post-mortem studies have determined that chronic active lesions are primarily related to the later stages of multiple sclerosis; however, the occurrence of these lesions, and their relationship to earlier disease stages may be greatly underestimated. Detection of chronic active lesions across the patient spectrum of multiple sclerosis requires a validated imaging tool to accurately identify lesions with persistent inflammation. Quantitative susceptibility mapping provides efficient in vivo quantification of susceptibility changes related to iron deposition and the potential to identify lesions harbouring iron-laden

SUBMITTER: Kaunzner UW 

PROVIDER: S-EPMC6308309 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature