Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity.

ABSTRACT: Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy. These conflicting results suggest that a single mechanism mediating the underlying neurophysiology of migraine symptoms is unlikely. The lack of a translational approach to study cranial allodynia reported in migraine patients is a limitation in dissecting potential mechanisms. Our objective was to study triptan-responsive cranial allodynia in migraine patients, and to develop an approach to studying its neural basis in the laboratory. Using nitroglycerine to trigger migraine attacks, we investigated whether cranial allodynia could be triggered experimentally, observing its response to treatment. Preclinically, we examined the cephali

SUBMITTER: Akerman S 

PROVIDER: S-EPMC6308314 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature