Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins.

ABSTRACT:

Introduction

Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFR_{cystatin C}) being less than 60% of creatinine-based estimated glomerular filtration rate (eGFR_creatinine) in the absence of extrarenal influences on the plasma levels of cystatin C or creatinine, is associated with a high increase in mortality, even in the absence of reduced glomerular filtration rate (GFR). The objective of the present study was to determine whether the proteome of patients with SPS shows differences from that of patients with normal or reduced measured GFR (mGFR) without SPS.

Methods

Four patient cohorts were included: 1 cohort with normal mGFR without SPS, 1 with normal mGFR with SPS, 1 with reduced mGFR without

SUBMITTER: Almen MS 

PROVIDER: S-EPMC6308389 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature