Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases.

ABSTRACT: The advances in cancer biology and pathogenesis during the past two decades, have resulted in immunotherapeutic strategies that have revolutionized the treatment of malignancies, from relatively non-selective toxic agents to specific, mechanism-based therapies. Despite extensive global efforts, infectious diseases remain a leading cause of morbidity and mortality worldwide, necessitating novel, innovative therapeutics that address the current challenges of increasing antimicrobial resistance. Similar to cancer pathogenesis, infectious pathogens successfully fashion a hospitable environment within the host and modulate host metabolic functions to support their nutritional requirements, while suppressing host defenses by altering regulatory mechanisms. These parallels, and the advances made

SUBMITTER: Naran K 

PROVIDER: S-EPMC6308495 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature