Soluble ST2 and Galectin-3 and Progression of CKD.

ABSTRACT:

Introduction

Cardiac biomarkers soluble ST2 (sST2) and galectin-3 may reflect cardiac inflammation and fibrosis. It is plausible that these mechanisms may also contribute to the progression of kidney disease. We examined associations of sST2 and galectin-3 with kidney function decline in participants with chronic kidney disease (CKD).

Methods

This was a pooled analysis of 2 longitudinal cohorts of participants with CKD: the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS). We measured circulating concentrations of sST2 and galectin-3 at baseline. Our primary outcome was progression to estimated glomerular filtration rate (eGFR) <15 ml/min per 1.73 m² or end-stage renal disease (ESRD). We used competing risk Cox regressio

SUBMITTER: Alam ML 

PROVIDER: S-EPMC6308819 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature