TRPV1 neurons regulate β-cell function in a sex-dependent manner.

ABSTRACT: There is emerging evidence to support an important role for the transient receptor potential vanilloid type 1 (TRPV1) sensory innervation in glucose homeostasis. However, it remains unknown whether the glucoregulatory action of these afferent neurons is sex-biased and whether it is pancreatic β-cell-mediated.

Objective

We investigated in male and female mice whether denervation of whole-body or pancreas-projecting TRPV1 sensory neurons regulates adult functional β-cell mass and alters systemic glucose homeostasis.

Methods

We used a combination of pharmacological and surgical approaches to ablate whole-body or pancreatic TRPV1 sensory neurons and assessed islet β-cell function and mass, aspects of glucose and insulin homeostasis, and energy expenditure.

Results

Capsaici

SUBMITTER: Bou Karam J 

PROVIDER: S-EPMC6308974 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature