Reconstructing high-resolution chromosome three-dimensional structures by Hi-C complex networks.

ABSTRACT:

Background

Hi-C data have been widely used to reconstruct chromosomal three-dimensional (3D) structures. One of the key limitations of Hi-C is the unclear relationship between spatial distance and the number of Hi-C contacts. Many methods used a fixed parameter when converting the number of Hi-C contacts to wish distances. However, a single parameter cannot properly explain the relationship between wish distances and genomic distances or the  locations of topologically associating domains (TADs).

Results

We have addressed one of the key issues of using Hi-C data, that is, the unclear relationship between spatial distances and the number of Hi-C contacts, which is crucial to understand significant biological functions, such as the enhancer-promoter interactions. Specifically,

SUBMITTER: Liu T 

PROVIDER: S-EPMC6309071 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature