Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8⁺ T cell responses.

ABSTRACT: Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers have been investigated previously as platforms for vaccines and immunotherapies and have been shown to raise immune responses in the absence of exogenous adjuvants and without measurable inflammation. However, at present it has not been tested whether the immunogenicity of these materials extends to the intranasal route. Here we investigated the extent to which self-assembled peptide nanofibers bearing an influenza peptide epitope elicit antigen-specific CD8⁺ T cell responses when delivered intranasally, and we compared these re

SUBMITTER: Si Y 

PROVIDER: S-EPMC6309200 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature