T-cell trafficking plays an essential role in tumor immunity.

ABSTRACT: Distinct populations of effector memory T cells use different homing receptors to traffic to the skin and gut. Whether tissue-selective T cells are needed for early rejection of a neoplasm growing in these tissues remains an open question. We chose to study an allogeneic tumor model because growth of such a fully mismatched tumor would signify a profound immune deficit. We implanted allogeneic tumor cells in the skin or gut of mice deficient in either α(1,3) fucosyltransferases IV and VII, enzymes critical for generating E-selectin ligands on skin-homing T cells, or β7 integrin, a component of the α4β7 integrin ligand for the mucosal adressin MAdCAM. During the first 9 days after tumor implantation, FucTVII^-/- mice showed a profoundly impaired capacity to reject tumors growing i

SUBMITTER: Aires DJ 

PROVIDER: S-EPMC6309214 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature