Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior.

ABSTRACT:

Importance

Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.

Objectives

To estimate the single-nucleotide polymorphism-based heritability of ASB; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to reevaluate the candidate gene era data through the Broad Antisocial Behavior Consortium.

Design, setting, and participants

Genome-wide association data from 5 large population-based cohorts and 3 target samples with genome-wide genotype and ASB data were used for meta-analysis from March 1, 2014, to M

SUBMITTER: Tielbeek JJ 

PROVIDER: S-EPMC6309228 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature