A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse.

ABSTRACT:

Rationale

Cardiac pacing is a critical technology for the treatment of arrhythmia and heart failure. The impact of specific pacing strategies on myocardial function is an area of intense research and high clinical significance. Mouse models have proven extremely useful for probing mechanisms of heart disease, but there is currently no reliable technology for long-term pacing in the mouse.

Objective

We sought to develop a device for long-term pacing studies in mice. We evaluated the device for (1) treating third-degree atrioventricular block after macrophage depletion, (2) ventricular pacing-induced cardiomyopathy, and (3) high-rate atrial pacing.

Methods and results

We developed a mouse pacemaker by refashioning a 26 mm×6.7 mm clinical device powered by a miniaturized

SUBMITTER: Hulsmans M 

PROVIDER: S-EPMC6309285 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature