Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury.

ABSTRACT: Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality in children. Experimental and clinical studies demonstrate that the developmental age, the type of injury (diffuse vs. focal) and sex may play important roles in the response of the developing brain to a traumatic injury. Advancements in acute neurosurgical interventions and neurocritical care have improved and led to a decrease in mortality rates over the past decades. However, survivors are left with life-long behavioral deficits underscoring the need to better define the cellular mechanisms underlying these functional changes. A better understanding of these mechanisms some of which begin in the acute post-traumatic period may likely lead to targeted treatment strategies. Key consideratio

SUBMITTER: Huh JW 

PROVIDER: S-EPMC6309300 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature