Periprocedural Stroke and Myocardial Infarction as Risks for Long-Term Mortality in CREST.

ABSTRACT:

Background

The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) previously reported increased mortality in patients who sustained a periprocedural stroke or cardiac event (myocardial infarction [MI] or biomarker only) in follow-up to 4 years. We now extend these observations to 10 years.

Methods and results

CREST is a randomized controlled trial designed to compare the outcomes of carotid stenting versus carotid endarterectomy. Proportional hazards models were used to assess the association between mortality and periprocedural stroke, MI, or biomarker-only events. For 10-year follow-up, patients with periprocedural stroke were at 1.74× the risk of death compared with those without stroke (adjusted hazard ratio [HR]=1.74; 95% CI, 1.21-2.50; P<0.003). Thi

SUBMITTER: Jones MR 

PROVIDER: S-EPMC6309309 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature