Timing Mechanisms Underlying Gate Control by Feedforward Inhibition.

ABSTRACT: The gate control theory proposes that Aβ mechanoreceptor inputs to spinal pain transmission T neurons are gated via feedforward inhibition, but it remains unclear how monosynaptic excitation is gated by disynaptic inhibitory inputs that arrive later. Here we report that Aβ-evoked, non-NMDAR-dependent EPSPs in T neurons are subthreshold, allowing time for inhibitory inputs to prevent action potential firing that requires slow-onset NMDAR activation. Potassium channel activities-including I_A, whose sizes are established constitutively by Preprodynorphin^Cre-derived inhibitory neurons-either completely filter away Aβ inputs or make them subthreshold, thereby creating a permissive condition to achieve gate control. Capsaicin-activated nociceptor inputs reduce I_A

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6309466 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature