Perinatal Nutrition and Programmed Risk for Neuropsychiatric Disorders: A Focus on Animal Models.

ABSTRACT: Maternal nutrition is critically important for fetal development. Recent human studies demonstrate a strong connection between diet during pregnancy and offspring risk for neuropsychiatric disorders including depression, anxiety, and attention-deficit/hyperactivity disorder. Animal models have emerged as a crucial tool for understanding maternal nutrition's contribution to prenatal programming and the later development of neuropsychiatric disorders. This review highlights preclinical studies examining how maternal consumption of the three macronutrients (protein, fats, and carbohydrates) influence offspring negative-valence behaviors relevant to neuropsychiatric disorders. We highlight the translational aspects of animal models and so examine exposure periods that mirror the neurodevelopme

SUBMITTER: DeCapo M 

PROVIDER: S-EPMC6309477 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature