Individualized survival prediction for patients with oropharyngeal cancer in the human papillomavirus era.

ABSTRACT:

Background

Accurate, individualized prognostication in patients with oropharyngeal squamous cell carcinoma (OPSCC) is vital for patient counseling and treatment decision making. With the emergence of human papillomavirus (HPV) as an important biomarker in OPSCC, calculators incorporating this variable have been developed. However, it is critical to characterize their accuracy prior to implementation.

Methods

Four OPSCC calculators were identified that integrate HPV into their estimation of 5-year overall survival. Treatment outcomes for 856 patients with OPSCC who were evaluated at a single institution from 2003 through 2016 were analyzed. Predicted survival probabilities were generated for each patient using each calculator. Calculator performance was assessed and compared

SUBMITTER: Beesley LJ 

PROVIDER: S-EPMC6309492 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature