The risk for drug abuse, alcohol use disorder, and psychosocial dysfunction in offspring from high-density pedigrees: its moderation by personal, family, and community factors.

ABSTRACT: Previous high-risk family designs in psychiatry have focused largely on offspring of affected parents. We take a pedigree-based approach and examine the social, psychological, and psychiatric features of offspring from extended pedigrees selected for high-densities of alcohol use disorder (AUD) or drug abuse (DA). We identified, from the Swedish population, 665,715 pedigrees containing a mean of 17.9 parents, aunts/uncles, grandparents, and cousins of a core full-sibship we term the pedigree offspring. We then derived 13 empirical classes of these pedigrees based on the density of cases of AUD and DA. High rates of AUD or DA in the pedigrees were associated in the offspring with lower levels of school achievement, educational attainment, and resilience, and higher rates of psychiatric illn

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC6309530 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature