Nontarget Analysis Reveals a Bacterial Metabolite of Pyrene Implicated in the Genotoxicity of Contaminated Soil after Bioremediation.

ABSTRACT: Bioremediation is an accepted technology for cleanup of soil contaminated with polycyclic aromatic hydrocarbons (PAHs), but it can increase the genotoxicity of the soil despite removal of the regulated PAHs. Although polar biotransformation products have been implicated as causative genotoxic agents, no specific product has been identified. We pursued a nontarget analytical approach combining effect-directed analysis (EDA) and metabolite profiling to compare extracts of PAH-contaminated soil from a former manufactured-gas plant site before and after treatment in a laboratory-scale aerobic bioreactor. A compound with the composition C₁₅H₈O₂ and four methylated homologues were shown to accumulate as a result of bioreactor treatment, and the C₁₅H

SUBMITTER: Tian Z 

PROVIDER: S-EPMC6309544 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature