Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III.

ABSTRACT:

Purpose

To find genetic contributions to glaucoma in African Americans.

Design

Cross-sectional, case-control study.

Participants

One thousand eight hundred seventy-five primary open-angle glaucoma (POAG) patients and 1709 controls, self-identified as being of African descent (AD), from the African Descent and Glaucoma Evaluation Study (ADAGES) III and Wake Forest School of Medicine.

Methods

MegaChip genotypes were imputed to Thousand Genomes data. Association of single nucleotide polymorphisms (SNPs) with POAG and advanced POAG was tested by linear mixed model correcting for relatedness and population stratification. Genetic risk scores were tested by receiver operator characteristic curves (ROC-AUCs).

Main outcome measures

Primary open-angle glaucoma de

SUBMITTER: Taylor KD 

PROVIDER: S-EPMC6309605 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature