Effect of Intensive Blood Pressure Lowering on Kidney Tubule Injury: Findings From the ACCORD Trial Study Participants.

ABSTRACT:

Rationale & objective

Random assignment to intensive blood pressure (BP) lowering (systolic BP<120mmHg) compared to a less intensive BP target (systolic BP<140mmHg) in the Action to Control Cardiovascular Risk in Diabetes BP (ACCORD-BP) trial resulted in a more rapid decline in estimated glomerular filtration rate (eGFR). Whether this reflects hemodynamic effects or intrinsic kidney damage is unknown.

Study design

Longitudinal analysis of a subgroup of clinical trial participants.

Settings & participants

A subgroup of 529 participants in ACCORD-BP.

Exposures

Urine biomarkers of tubular injury (kidney injury molecule 1, interleukin 18 [IL-18]), repair (human cartilage glycoprotein 39 [YKL-40]), and inflammation (monocyte chemoattractant protein 1) at baseline an

SUBMITTER: Nadkarni GN 

PROVIDER: S-EPMC6309631 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature