Using All Longitudinal Data to Define Time to Specified Percentages of Estimated GFR Decline: A Simulation Study.

ABSTRACT:

Rationale & objective

The standard method to calculate time to the event of a specified percentage decline in estimated glomerular filtration rate (eGFR) uses 2 eGFR assessments, 1 at baseline and 1 at the event time. However, event times may be inaccurate due to eGFR variability and restriction of events to study visit times. We propose a novel method for calculating time to a specified percentage decline in eGFR that uses all available longitudinal eGFR assessments.

Study design

Simulation study and comparison of methods in 2 observational cohorts.

Settings & participants

Simulation data and study participants in the Nephrotic Syndrome Study Network (NEPTUNE) and Clinical Phenotyping and Resource Biobank Core (C-PROBE).

Exposure

Analytical method for calculat

SUBMITTER: Zee J 

PROVIDER: S-EPMC6309673 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature