Pleiotropy of the Drosophila melanogaster foraging gene on larval feeding-related traits.

ABSTRACT: Little is known about the molecular underpinning of behavioral pleiotropy. The Drosophila melanogaster foraging gene is highly pleiotropic, affecting many independent larval and adult phenotypes. Included in foraging's multiple phenotypes are larval foraging path length, triglyceride levels, and food intake. foraging has a complex structure with four promoters and 21 transcripts that encode nine protein isoforms of a cGMP dependent protein kinase (PKG). We examined if foraging's complex molecular structure underlies the behavioral pleiotropy associated with this gene. Using a promotor analysis strategy, we cloned DNA fragments upstream of each of foraging's transcription start sites and generated four separate for^pr-Gal4s. Supporting our hypothesis of modular function, they had

SUBMITTER: Allen AM 

PROVIDER: S-EPMC6309726 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature