Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients.

ABSTRACT:

Objectives

Microbial infections and mucosal dysbiosis influence morbidity in patients with systemic lupus erythematosus (SLE). In the oral cavity, periodontal bacteria and subgingival plaque dysbiosis provide persistent inflammatory stimuli at the mucosal surface. This study was undertaken to evaluate whether exposure to periodontal bacteria influences disease parameters in SLE patients.

Methods

Circulating antibodies to specific periodontal bacteria have been used as surrogate markers to determine an ongoing bacterial burden, or as indicators of past exposure to the bacteria. Banked serum samples from SLE patients in the Oklahoma Lupus Cohort were used to measure antibody titres against periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis,

SUBMITTER: Bagavant H 

PROVIDER: S-EPMC6309750 | biostudies-literature | 2019 Jan-Feb

REPOSITORIES: biostudies-literature