A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open-source tool for histological grading.

ABSTRACT:

Objective

In osteoarthritis (OA) models, histology is commonly used to evaluate the severity of joint damage. Unfortunately, semi-quantitative histological grading systems include some level of subjectivity, and quantitative grading systems can be tedious to implement. The objective of this work is to introduce an open source, graphic user interface (GUI) for quantitative grading of knee OA.

Methods

Inspired by the 2010 OARSI histopathology recommendations for the rat, our laboratory has developed a GUI for the evaluation of knee OA, nicknamed GEKO. In this work, descriptions of the quantitative measures acquired by GEKO are presented and measured in 42 histological images from a rat knee OA model. Using these images, across-session and within-session reproducibility for ind

SUBMITTER: Kloefkorn HE 

PROVIDER: S-EPMC6309770 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature