Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 ^V617F Mice.

ABSTRACT:

Rationale

The mechanisms driving atherothrombotic risk in individuals with JAK2 ^V617F ( Jak2 ^VF) positive clonal hematopoiesis or myeloproliferative neoplasms are poorly understood.

Objective

The goal of this study was to assess atherosclerosis and underlying mechanisms in hypercholesterolemic mice with hematopoietic Jak2 ^VF expression.

Methods and results

Irradiated low-density lipoprotein receptor knockout ( Ldlr^-/-) mice were transplanted with bone marrow from wild-type or Jak2 ^VF mice and fed a high-fat high-cholesterol Western diet. Hematopoietic functions and atherosclerosis were characterized. After 7 weeks of Western diet, Jak2 ^VF mice showed increased atherosclerosis. Early atherosclerotic lesi

SUBMITTER: Wang W 

PROVIDER: S-EPMC6309796 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature