Proximal Tubule-Specific Deletion of the NHE3 (Na⁺/H⁺ Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice.

ABSTRACT: The present study directly tested the hypothesis that deletion of the NHE3 (Na⁺/H⁺ exchanger 3) selectively in the proximal tubules of the kidney lowers basal blood pressure by increasing the pressure-natriuresis response in mice. Adult male and female, age-matched wild-type (WT) littermates and proximal tubule-specific NHE3 knockout mice (PT- Nhe3^-/-; n=6-16 per group) were studied for (1) basal phenotypes of electrolytes and pH, blood pressure, and kidney function; (2) the pressure-natriuresis response using the mesenteric, celiac, and abdominal arterial occlusion technique; and (3) the natriuretic responses to acute saline expansion (0.9% NaCl, 10% body weight, intraperitoneal) or 2-week of 2% NaCl diet. Under basal conditions, PT- Nhe3^-/- mic

SUBMITTER: Li XC 

PROVIDER: S-EPMC6309803 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature