Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients.

ABSTRACT:

Objectives

Numbness associated with neuropathic pain suggests the loss of function in myelinated, large diameter sensory neurons. The purpose of this study was to examine the relationships between pain severity and subjective (ie, severity of numbness) and objective (ie, loss of light touch sensations, vibration thresholds) measures of loss of large fiber function in adult survivors with chemotherapy-induced peripheral neuropathy (CIPN, n=426) and breast cancer patients with persistent postsurgical pain (n=80).

Material and methods

For both samples, average pain and numbness were evaluated using a 0 to 10 numeric rating scale. Loss of light touch sensations in the hands and feet of patients with CIPN and in the upper arm of patients at 5 and 6 months following breast cancer

SUBMITTER: Miaskowski C 

PROVIDER: S-EPMC6309865 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature