The physiology and toxicology of acute inhalation phosphine poisoning in conscious male rats.

ABSTRACT: Phosphine (PH₃) is a toxidrome-spanning chemical that is widely used as an insecticide and rodenticide. Exposure to PH₃ causes a host of target organ and systemic effects, including oxidative stress, cardiopulmonary toxicity, seizure-like activity and overall metabolic disturbance. A custom dynamic inhalation gas exposure system was designed for the whole-body exposure of conscious male Sprague-Dawley rats (250-350 g) to PH₃. An integrated plethysmography system was used to collect respiratory parameters in real-time before, during and after PH₃ exposure. At several time points post-exposure, rats were euthanized, and various organs were removed and analyzed to assess organ and systemic effects. The 24 h post-exposure LCt₅₀, determined

SUBMITTER: Wong B 

PROVIDER: S-EPMC6309866 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature