Ontology highlight
ABSTRACT:
SUBMITTER: Rack JGM
PROVIDER: S-EPMC6309922 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Rack Johannes Gregor Matthias JGM Ariza Antonio A Drown Bryon S BS Henfrey Callum C Bartlett Edward E Shirai Tomohiro T Hergenrother Paul J PJ Ahel Ivan I
Cell chemical biology 20181121 12
Protein ADP-ribosylation is a highly dynamic post-translational modification. The rapid turnover is achieved, among others, by ADP-(ribosyl)hydrolases (ARHs), an ancient family of enzymes that reverses this modification. Recently ARHs came into focus due to their role as regulators of cellular stresses and tumor suppressors. Here we present a comprehensive structural analysis of the enzymatically active family members ARH1 and ARH3. These two enzymes have very distinct substrate requirements. Ou ...[more]