Donor Urinary C5a Levels Independently Correlate With Posttransplant Delayed Graft Function.

ABSTRACT:

Background

Accumulating evidence implicates the complement cascade as pathogenically contributing to ischemia-reperfusion injury and delayed graft function (DGF) in human kidney transplant recipients. Building on observations that kidney injury can initiate in the donor before nephrectomy, we tested the hypothesis that anaphylatoxins C3a and C5a in donor urine before transplantation associate with risk of posttransplant injury.

Methods

We evaluated the effects of C3a and C5a in donor urine on outcomes of 469 deceased donors and their corresponding 902 kidney recipients in a subset of a prospective cohort study.

Results

We found a threefold increase of urinary C5a concentrations in donors with stage 2 and 3 acute kidney injury (AKI) compared donors without AKI (P < 0.0

SUBMITTER: Schroppel B 

PROVIDER: S-EPMC6309924 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature