Defining the molecular signatures of human right heart failure.

ABSTRACT:

Aims

Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF.

Materials and methods

We analyzed mRNA of human non-failing LV and RV samples and RVF samples from patients with pulmonary arterial hypertension (PAH), and post-LVAD implantation. We then performed transcript analysis to determine differential expression of genes in the human heart samples. Immunoblot quantification was performed followed by analysis of non-failing and failing phenotypes.

Key findings

Inflammatory pathways were more commonly dysregulated in RV tissue (both non-failing and failing phenotypes). In

SUBMITTER: Williams JL 

PROVIDER: S-EPMC6310003 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature