Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms.

ABSTRACT: Congenital heart disease (CHD) is the most common type of birth defect and is both a significant pediatric and adult health problem, in light of a growing population of survivors. The etiology of CHD has been considered to be multifactorial with genetic and environmental factors playing important roles. The combination of advances in cardiac developmental biology, which have resulted in the elucidation of molecular pathways regulating normal cardiac morphogenesis, and genome sequencing technology have allowed the discovery of numerous genetic contributors of CHD ranging from chromosomal abnormalities to single gene variants. Conversely, mechanistic details of the contribution of environmental factors to CHD remain unknown. Maternal diabetes mellitus (matDM) is a well-established and increa

SUBMITTER: Basu M 

PROVIDER: S-EPMC6310016 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature