Genomic Risk Stratification Predicts All-Cause Mortality After Cardiac Catheterization.

ABSTRACT:

Background

Coronary artery disease (CAD) is influenced by genetic variation and traditional risk factors. Polygenic risk scores (PRS), which can be ascertained before the development of traditional risk factors, have been shown to identify individuals at elevated risk of CAD. Here, we demonstrate that a genome-wide PRS for CAD predicts all-cause mortality after accounting for not only traditional cardiovascular risk factors but also angiographic CAD itself.

Methods

Individuals who underwent coronary angiography and were enrolled in an institutional biobank were included; those with prior myocardial infarction or heart transplant were excluded. Using a pruning-and-thresholding approach, a genome-wide PRS comprised of 139 239 variants was calculated for 1503 participants who u

SUBMITTER: Levin MG 

PROVIDER: S-EPMC6310018 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature