Neurologic impairments from pediatric low-grade glioma by tumor location and timing of diagnosis.

ABSTRACT: BACKGROUND:The neurologic outcomes of low-grade gliomas (LGGs) according to tumor location and duration of presenting symptoms remain poorly characterized in children. PROCEDURE:We retrospectively reviewed neurologic impairments in 246 pediatric patients with LGGs (88 with optic pathway and midline tumors, 56 with posterior fossa tumors, 52 with cerebral hemisphere tumors, 35 with brainstem tumors, and 15 with spinal cord tumors) who were treated at St. Jude Children's Research Hospital between 1995 and 2005. We compared neurologic impairments (defined by Common Terminology Criteria for Adverse Events, version 4.03) by tumor location and prediagnosis symptom interval (PSI) (≥ 3 months or < 3 months) at first and last patient visits. RESULTS:The median age of diagnosis was 7.1 years; median

SUBMITTER: Sadighi ZS 

PROVIDER: S-EPMC6310055 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature