Joint Detection of Associations between DNA Methylation and Gene Expression from Multiple Cancers.

ABSTRACT: DNA methylation plays an important role in the development of various cancers mainly through the regulation on gene expression. Hence, the study on the relation between DNA methylation and gene expression is of particular interest to understand cancers. Recently, an increasing number of datasets are available from multiple cancers, which makes it possible to study both the similarity and difference of genomic alterations across multiple tumor types. However, most of the existing pan-cancer analysis methods perform simple aggregations, which may overlook the heterogeneity of the interactions. In this paper, we propose a novel method to jointly detect complex associations between DNA methylation and gene expression levels from multiple cancers. The main idea is to apply joint sparse canonica

SUBMITTER: Fang J 

PROVIDER: S-EPMC6310112 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature