Interferon-gamma response to the treatment of active pulmonary and extra-pulmonary tuberculosis.

ABSTRACT:

Background

Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not to measure treatment response.

Objective

To measure IFN-γ response to active anti-tuberculosis treatment.

Design

Patients from the Henan Provincial Chest Hospital, Henan, China, with TB symptoms and/or signs were enrolled into this prospective, observational cohort study and followed for 6 months of treatment, with blood and sputum samples collected at 0, 2, 4, 6, 8, 16 and 24 weeks. The QuantiFERON® TB-Gold assay was run on collected blood samples. Participants received a follow-up telephone call at 24 months to determine relapse status.

Results

Of the 152 TB patients enrolled, 135 were eligible for this analysis: 118 pulmonary (PTB) and 17 extra-pulmonary

SUBMITTER: Liang L 

PROVIDER: S-EPMC6310125 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature