Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy.

ABSTRACT: The interaction between radionuclides and nanomaterials could generate Cerenkov radiation (CR) for CR-induced photodynamic therapy (PDT) without requirement of external light excitation. However, the relatively weak CR interaction leaves clinicians uncertain about the benefits of this new type of PDT. Therefore, a novel strategy to amplify the therapeutic effect of CR-induced PDT is imminently required to overcome the disadvantages of traditional nanoparticulate PDT such as tissue penetration limitation, external light dependence, and low tumor accumulation of photosensitizers. Herein, magnetic nanoparticles (MNPs) with ⁸⁹Zr radiolabeling and porphyrin molecules (TCPP) surface modification (i.e., ⁸⁹Zr-MNP/TCPP) were synthesized for CR-induced PDT with magnetic targeti

SUBMITTER: Ni D 

PROVIDER: S-EPMC6310174 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature