APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality.

ABSTRACT: Background and Purpose- The role of dietary fat on cardiovascular health and mortality remains under debate. Because the APOE is central to the transport and metabolism of lipids, we examined associations between plasma fatty acids and the risk of stroke, coronary heart disease, and mortality by APOE-ε4 genotype. Methods- We included 943 FHS (Framingham Heart Study) and 1406 3C (Three-City) Bordeaux Study participants. Plasma docosahexaenoic, linoleic, arachidonic, and palmitic fatty acids were measured at baseline by gas chromatography. All-cause stroke, ischemic stroke, coronary heart disease, and all-cause mortality events were identified prospectively using standardized protocols. Each cohort used Cox models to separately relate fatty acid levels to the risk of developing each event du

SUBMITTER: Satizabal CL 

PROVIDER: S-EPMC6310220 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature