Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain.

ABSTRACT: In utero alcohol exposure can cause fetal alcohol spectrum disorders (FASD), characterized by structural brain abnormalities and long-lasting behavioral and cognitive dysfunction. Neuronal plasticity is affected by in utero alcohol exposure and can be modulated by extracellular proteolysis. Plasmin is a major extracellular serine-protease whose activation is tightly regulated by the plasminogen activator (PA) system. In the present study we explored the effect of ethanol on the expression of the main components of the brain PA system in sex-specific cortical astrocyte primary cultures in vitro and in the cortex and hippocampus of post-natal day (PD) 9 male and female rats. We find that ethanol alters the PA system in astrocytes and in the developing brain. In particular, the expression of

SUBMITTER: Wilhelm CJ 

PROVIDER: S-EPMC6310223 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature