Serum amyloid a as an indicator of impending xenograft failure: Experimental studies.

ABSTRACT:

Background

There is well-documented systemic inflammatory response in xenograft recipients to the presence of a pig graft. Serum amyloid A (SAA) is an inflammatory marker that is elevated in various pathological states. The assay used to measure it is (i) simple, (ii) relatively inexpensive, and (iii) provides an answer within minutes.

Method

The levels of SAA (n = 11) and C-reactive protein (C-RP) (n = 8) were measured retrospectively in the serum of baboons with pig kidney transplants, who received therapy with an IL-6R inhibitor and a TNF-α antagonist. Immunohistochemistry (IHC) was used to identify amyloid A and C-RP expression in the native livers and deposition in the pig kidney grafts.

Results

One kidney graft underwent hyperacute rejection, 6 (55%) underwent a

SUBMITTER: Zhang G 

PROVIDER: S-EPMC6310230 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature