Assessing the sensitivity of the polio environmental surveillance system.

ABSTRACT:

Background

The polio environmental surveillance (ES) system has been an incredible tool for advancing polio eradication efforts because of its ability to highlight the spatial and temporal extent of poliovirus circulation. While ES often outperforms, or is more sensitive than AFP surveillance, the sensitivity of the ES system has not been well characterized. Fundamental uncertainty of ES site sensitivity makes it difficult to interpret results from ES, particularly negative results.

Methods and findings

To study ES sensitivity, we used data from Afghanistan and Pakistan to examine the probability that each ES site detected the Sabin 1, 2, or 3 components of the oral polio vaccine (OPV) as a function of virus prevalence within the same district (estimated from AFP data). Acco

SUBMITTER: Kroiss SJ 

PROVIDER: S-EPMC6310268 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature