Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography.

ABSTRACT:

Purpose

To assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE).

Methods

A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k, defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from corneal bending). Elastograph

SUBMITTER: De Stefano VS 

PROVIDER: S-EPMC6310362 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature