ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness.

ABSTRACT:

Purpose

Muscle injury is the most common sports injury. Muscle stiffness, a risk factor for muscle injury, is lower in females than in males, implying that sex-related genetic polymorphisms influence muscle injury associated with muscle stiffness. The present study aimed to clarify the associations between two genetic polymorphisms (rs2234693 and rs9340799) in the estrogen receptor 1 gene (ESR1) and muscle injury or muscle stiffness.

Methods

In study 1, a questionnaire was used to assess the muscle injury history of 1311 Japanese top-level athletes. In study 2, stiffness of the hamstring muscles was assessed using ultrasound shear wave elastography in 261 physically active young adults. In both studies, rs2234693 C/T and rs9340799 G/A polymorphisms in the ESR1 were analyzed

SUBMITTER: Kumagai H 

PROVIDER: S-EPMC6310456 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature